Harvey Cushing was one of the pioneers of American neurosurgery. In the course of a long operating career, he treated many people for diseases of the brain and nervous system, and he acquired an extensive collection of brains and brain section that illustrate various stages in the course of illness. These specimens were regarded as extremely valuable teaching resources for physicians and medical students, in the days before extensive imaging technologies had been developed. Cushing left the collection to Yale University, but, one thing leading to another, as they say, the various jars and bottles were moved around, displaced, misplaced, separated and lost sight of. Moreover the careful annotations about histological type, extent of involvement, age of patient and similar data were mixed up or lost. Now, the Harvey Cushing Center at Yale has gathered about 500 of the original specimens and made them available with proper identification in a special display area devoted to the collection. Cushing was present at the creation of neurosurgery, and not only present, but active in shaping it into the careful, disciplined and methodical operative technique it is today. Cushing was famous for his judgment about where tumors could be found, how to approach them surgically, and how to avoid “collateral damage” to healthy tissue. At the time, neurosurgeons were writing the play and acting it out at the same time. Somebody had to go first, and he did.