Keeping Kids Healthy – Childhood cancer often is a random mistake in DNA instructions

Drs. Sally Robinson & Keith Bly

Drs. Sally Robinson & Keith Bly

Keeping Kids Healthy

The word “cancer” certainly strikes a scary and emotional note in our hearts, and when attached to the word “childhood,” it can be especially frightening.

However, as with many things we fear, we can be empowered by understanding. This week, we explain just exactly what cancer really is.

Every part of the body (the brain, liver, heart, bones, fingernails, muscles and so on) is made up of hundreds of millions of microscopic cells that are specialized for that particular organ.

These cells follow a very complex and highly organized instruction set from their DNA to multiply, grow and eventually die and become replaced throughout our entire lifetimes.

Occasionally, however, the instruction set becomes damaged as it is copied into newly formed cells. Usually our bodies can recognize cells with damaged DNA and repairs or destroys them.

But sometimes when the instruction to “stop multiplying” is damaged, cells can multiply and grow out of control faster than our bodies can repair the damage. This is how cancer begins.

If the out-of-control cells come from a solid organ like the liver, brain or a muscle, a cancerous tumor is formed. If the out of control cells originate from the blood, such as in leukemia, no tumor is usually formed, but the cancer cells are circulated throughout the body in the bloodstream.

When cancer cells break off from a solid tumor and travel through the blood to other parts of the body and start new tumors, this is called metastasis.

Cancer cells can be very aggressive and start to crowd out and steal energy and nutrients from normal cells so that healthy body parts can no longer function correctly.

In children, the DNA damage that starts the formation of a cancer is not typically caused by any identifiable cause or lifestyle habit such as smoking.

Rather, it is more often a random mistake in the DNA instructions of cells that are rapidly multiplying during the normal growth process of children.

This partly explains why some of the most common cancers in children are of the blood, brain and bones.

Next week we’ll discuss the some of the different types and early warning signs of childhood cancers.

Sally Robinson is a clinical professor of pediatrics at UTMB Children’s Hospital, and Keith Bly is an associate professor of pediatrics and director of the UTMB Pediatric Urgent Care Clinics. This column isn’t intended to replace the advice of your child’s physician.

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