TRCC (Texas Regional CTSA Consortium) Quantitative Seminar Series

“Evaluating Community-Based Translational Interventions Using Historical Controls: Propensity Score vs. Disease Risk Score Approach”

Luohua Jiang, Ph.D.

Associate Professor- Department of Epidemiology University of California, Irvine

Tuesday, August 25, 2020 Noon – 1 pm Virtual (Zoom)

This seminar contributes to achieving one or more of the CTSA core competencies in the category of Statistical Approaches.

Abstract: Many community-based translations of evidence-based interventions are designed as one-arm studies due to ethical and other considerations. Evaluating the impacts of such programs is challenging. Here we examine the effectiveness of the lifestyle intervention implemented by the Special Diabetes Program for Indians Diabetes Prevention (SDPI-DP) demonstration project, a translational lifestyle intervention among American Indian and Alaska Native communities. Data from the landmark Diabetes Prevention Program placebo group was used as a historical control. We compared the use of propensity score (PS) and disease risk score (DRS) matching to adjust for potential confounder imbalance between groups. The unadjusted hazard ratio (HR) for diabetes risk was 0.35 for SDPI-DP lifestyle intervention vs. control. However, when relevant diabetes risk factors were considered, the adjusted HR estimates were attenuated toward 1. The differences in estimated HRs using the PS and DRS approaches were relatively small but DRS matching resulted in more participants being matched and smaller standard errors of effect estimates. Carefully employed, publicly available randomized clinical trial data can be used as a historical control to evaluate the intervention effectiveness of one-arm community translational initiatives. It is critical to use a proper statistical method to balance the distributions of potential confounders between comparison groups in this kind of evaluations.

Participating TRCC Institutions include: UTMB, UTHSC-Houston, UTHSC-San Antonio, and UT Southwestern

For Zoom Meeting information please contact Casey Sendejas.

UTMB offers its employees and volunteers free flu shots each year to help prevent the spread of seasonal influenza.         

The 2020–2021 Flu Free program is provided in partnership with UT SELECT, a PPO plan administered by Blue Cross and Blue Shield of Texas, and vaccinations are available Sept. 29 – Oct. 1 from 7 a.m. to noon in the Jenny Sealy Hospital and the John Sealy Hospital on the Galveston Campus.

Employees and volunteers who receive a flu shot at a UTMB facility this year are asked to complete an online attestation/consent as proof of vaccination. The attestation/consent is available at https://utmb.us/4di and should be submitted within 24 hours of being vaccinated. 

For more details about the university’s vaccination program and how to receive your flu shot, click here.

UTMB offers its employees and volunteers free flu shots each year to help prevent the spread of seasonal influenza.

The 2020–2021 Flu Free program is provided in partnership with UT SELECT, a PPO plan administered by Blue Cross and Blue Shield of Texas, and vaccinations are available every Tuesday and Thursday from Sept. 29 to Oct. 29 between 7 a.m. and noon in the Clear Lake Campus Hospital.

Employees and volunteers who receive a flu shot at a UTMB facility this year are asked to complete an online attestation/consent as proof of vaccination. The attestation/consent is available at https://utmb.us/4di and should be submitted within 24 hours of being vaccinated. 

For more details about the university’s vaccination program and how to receive your flu shot, click here.

UTMB offers its employees and volunteers free flu shots each year to help prevent the spread of seasonal influenza.

The 2020–2021 Flu Free program is provided in partnership with UT SELECT, a PPO plan administered by Blue Cross and Blue Shield of Texas, and vaccinations are now available at the Angleton Danbury Campus Hospital by contacting Olivia Garner at omgarner@utmb.edu between 9 a.m. and 2 p.m.

Employees and volunteers who receive a flu shot at a UTMB facility this year are asked to complete an online attestation/consent as proof of vaccination. The attestation/consent is available at https://utmb.us/4di and should be submitted within 24 hours of being vaccinated. 

For more details about the university’s vaccination program and how to receive your flu shot, click here.

UTMB offers its employees and volunteers free flu shots each year to help prevent the spread of seasonal influenza.         

The 2020–2021 Flu Free program is provided in partnership with UT SELECT, a PPO plan administered by Blue Cross and Blue Shield of Texas, and vaccinations are available Oct. 6 – 8 from 7 a.m. to noon in the Jenny Sealy Hospital and the John Sealy Hospital on the Galveston Campus.

Employees and volunteers who receive a flu shot at a UTMB facility this year are asked to complete an online attestation/consent as proof of vaccination. The attestation/consent is available at https://utmb.us/4di and should be submitted within 24 hours of being vaccinated. 

For more details about the university’s vaccination program and how to receive your flu shot, click here.